He used to be a successful businessman, but drug ____ his ruin.

You had better ______some time every day for sports so that you can keep yourself energetic.

— How are you, my dear?— Not so well． I've ___ the flu．

We’d better _________ when he is thinking, as he prefers to solve problems on his own. 

— How do you find the town you visited yesterday?— The town has changed out of all ______ in the past 20 years, a completely new one in front of me.