Mr Smith, looking ______, started to work out a        problem.

I thought it was __________ to donate money to this fund.

Would it be ___ for you to pick me up at four o’clock and take me to the airport? 

Since　the　matter　was　extremely＿＿，we　dealt　with　it　immediately．　　

 .Without any doubt, depression________can create a variety of negative health effect.