_______ you think graffiti (涂鸦) is mindless vandalism(破坏行为) against property or a living art form, its popularity suggests that it is here to stay.

Europeans always hold their fork in the left hand, ________Americans switch it between their left and right hands.

______ he has made up his mind, no one can make him change it.

Thanks for your kind help! We would have _________ lost the game!

In the global economy, a new drug for cancer, _________ it is discovered, will create many economic possibilities around the world.