It is no good ______ him. He doesn’t help himself.

It is reported that people are         likely to tell lies over the phone as they are in emails. 

________ to tell him the news；he has been told of it.

 — You look sad. ____?— Oh, my grandmother’s very ill.

When ______ comes to research into heart disease and its effects on the body, we do not have adequate substitutes for the use of animals.